Characterization of the Kynurenine Pathway and Quinolinic Acid Production in Macaque Macrophages
Identifieur interne : 004796 ( Main/Exploration ); précédent : 004795; suivant : 004797Characterization of the Kynurenine Pathway and Quinolinic Acid Production in Macaque Macrophages
Auteurs : Chai K. Lim [Australie] ; Margaret M. C. Yap [Australie] ; Stephen J. Kent [Australie] ; Gabriel Gras [France] ; Boubekeur Samah [France] ; Jane C. Batten [Australie] ; Robert De Rose [Australie] ; Benjamin Heng [Australie] ; Bruce J. Brew [Australie] ; Gilles J. Guillemin [Australie]Source :
- International Journal of Tryptophan Research : IJTR [ 1178-6469 ] ; 2013.
Abstract
The kynurenine pathway (KP) and one of its end-products, the excitotoxin quinolinic acid (QUIN), are involved in the pathogenesis of several major neuroinflammatory brain diseases. A relevant animal model to study KP metabolism is now needed to assess whether intervention in this pathway may improve the outcome of such diseases. Humans and macaques share a very similar genetic makeup. In this study, we characterized the KP metabolism in macaque primary macrophages of three different species in comparison to human cells. We found that the KP profiles in simian macrophages were very similar to those in humans when challenged with inflammatory cytokines. Further, we found that macaque macrophages are capable of producing a pathophysiological concentration of QUIN. Our data validate the simian model as a relevant model to study the human cellular KP metabolism in the context of inflammation.
Url:
DOI: 10.4137/IJTR.S11789
PubMed: 23761975
PubMed Central: 3662399
Affiliations:
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Lim</name><affiliation wicri:level="3"><nlm:aff id="af1-ijtr-6-2013-007">Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijtr-6-2013-007">MND and Neurodegenerative disease Research Group, Australian School of Advance Medicine, Macquarie University, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>MND and Neurodegenerative disease Research Group, Australian School of Advance Medicine, Macquarie University</wicri:regionArea><wicri:noRegion>Macquarie University</wicri:noRegion></affiliation></author><author><name sortKey="Yap, Margaret M C" sort="Yap, Margaret M C" uniqKey="Yap M" first="Margaret M. C." last="Yap">Margaret M. C. Yap</name><affiliation wicri:level="3"><nlm:aff id="af3-ijtr-6-2013-007">Applied Neurosciences, St. Vincent’s Center for Applied Medical Research, Sydney, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Applied Neurosciences, St. Vincent’s Center for Applied Medical Research, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Kent, Stephen J" sort="Kent, Stephen J" uniqKey="Kent S" first="Stephen J." last="Kent">Stephen J. Kent</name><affiliation wicri:level="4"><nlm:aff id="af4-ijtr-6-2013-007">Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Gras, Gabriel" sort="Gras, Gabriel" uniqKey="Gras G" first="Gabriel" last="Gras">Gabriel Gras</name><affiliation wicri:level="1"><nlm:aff id="af5-ijtr-6-2013-007">Laboratoire de Neuro-Immuno-Virologie, Service de Neurovirologie UMR E-01 CEA, France and UMR E1, School of Medicine, University Paris South 11, Le Kremlin-Bicêtre, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratoire de Neuro-Immuno-Virologie, Service de Neurovirologie UMR E-01 CEA, France and UMR E1, School of Medicine, University Paris South 11, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Samah, Boubekeur" sort="Samah, Boubekeur" uniqKey="Samah B" first="Boubekeur" last="Samah">Boubekeur Samah</name><affiliation wicri:level="1"><nlm:aff id="af5-ijtr-6-2013-007">Laboratoire de Neuro-Immuno-Virologie, Service de Neurovirologie UMR E-01 CEA, France and UMR E1, School of Medicine, University Paris South 11, Le Kremlin-Bicêtre, France.</nlm:aff><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Laboratoire de Neuro-Immuno-Virologie, Service de Neurovirologie UMR E-01 CEA, France and UMR E1, School of Medicine, University Paris South 11, Le Kremlin-Bicêtre</wicri:regionArea><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion><wicri:noRegion>Le Kremlin-Bicêtre</wicri:noRegion></affiliation></author><author><name sortKey="Batten, Jane C" sort="Batten, Jane C" uniqKey="Batten J" first="Jane C." last="Batten">Jane C. Batten</name><affiliation wicri:level="4"><nlm:aff id="af4-ijtr-6-2013-007">Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="De Rose, Robert" sort="De Rose, Robert" uniqKey="De Rose R" first="Robert" last="De Rose">Robert De Rose</name><affiliation wicri:level="4"><nlm:aff id="af4-ijtr-6-2013-007">Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Heng, Benjamin" sort="Heng, Benjamin" uniqKey="Heng B" first="Benjamin" last="Heng">Benjamin Heng</name><affiliation wicri:level="1"><nlm:aff id="af2-ijtr-6-2013-007">MND and Neurodegenerative disease Research Group, Australian School of Advance Medicine, Macquarie University, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>MND and Neurodegenerative disease Research Group, Australian School of Advance Medicine, Macquarie University</wicri:regionArea><wicri:noRegion>Macquarie University</wicri:noRegion></affiliation></author><author><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><affiliation wicri:level="3"><nlm:aff id="af3-ijtr-6-2013-007">Applied Neurosciences, St. Vincent’s Center for Applied Medical Research, Sydney, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Applied Neurosciences, St. Vincent’s Center for Applied Medical Research, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af6-ijtr-6-2013-007">Department of Neurology, St. Vincent’s Hospital, Darlinghurst, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Neurology, St. Vincent’s Hospital, Darlinghurst</wicri:regionArea><wicri:noRegion>Darlinghurst</wicri:noRegion></affiliation></author><author><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><affiliation wicri:level="3"><nlm:aff id="af1-ijtr-6-2013-007">Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-ijtr-6-2013-007">MND and Neurodegenerative disease Research Group, Australian School of Advance Medicine, Macquarie University, Australia.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Australie</country><wicri:regionArea>MND and Neurodegenerative disease Research Group, Australian School of Advance Medicine, Macquarie University</wicri:regionArea><wicri:noRegion>Macquarie University</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Tryptophan Research : IJTR</title><idno type="eISSN">1178-6469</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The kynurenine pathway (KP) and one of its end-products, the excitotoxin quinolinic acid (QUIN), are involved in the pathogenesis of several major neuroinflammatory brain diseases. A relevant animal model to study KP metabolism is now needed to assess whether intervention in this pathway may improve the outcome of such diseases. Humans and macaques share a very similar genetic makeup. In this study, we characterized the KP metabolism in macaque primary macrophages of three different species in comparison to human cells. We found that the KP profiles in simian macrophages were very similar to those in humans when challenged with inflammatory cytokines. Further, we found that macaque macrophages are capable of producing a pathophysiological concentration of QUIN. Our data validate the simian model as a relevant model to study the human cellular KP metabolism in the context of inflammation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Braidy, N" uniqKey="Braidy N">N Braidy</name></author><author><name sortKey="Grant, R" uniqKey="Grant R">R Grant</name></author><author><name sortKey="Brew, Bj" uniqKey="Brew B">BJ Brew</name></author><author><name sortKey="Adams, S" uniqKey="Adams S">S Adams</name></author><author><name sortKey="Jayasena, T" uniqKey="Jayasena T">T Jayasena</name></author><author><name sortKey="Guillemin, Gj" uniqKey="Guillemin G">GJ Guillemin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munn, Dh" uniqKey="Munn D">DH Munn</name></author><author><name sortKey="Zhou, M" uniqKey="Zhou M">M Zhou</name></author><author><name sortKey="Attwood, Jt" uniqKey="Attwood J">JT 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uniqKey="Heyes M">MP Heyes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guillemin, Gj" uniqKey="Guillemin G">GJ Guillemin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heyes, Mp" uniqKey="Heyes M">MP Heyes</name></author><author><name sortKey="Saito, K" uniqKey="Saito K">K Saito</name></author><author><name sortKey="Markey, Sp" uniqKey="Markey S">SP Markey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samadi, P" uniqKey="Samadi P">P Samadi</name></author><author><name sortKey="Gregoire, L" uniqKey="Gregoire L">L Gregoire</name></author><author><name sortKey="Rassoulpour, A" uniqKey="Rassoulpour A">A Rassoulpour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Kc" uniqKey="Williams K">KC Williams</name></author><author><name sortKey="Corey, S" uniqKey="Corey S">S Corey</name></author><author><name sortKey="Westmoreland, Sv" uniqKey="Westmoreland S">SV Westmoreland</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Nouvelle-Galles du Sud</li><li>Victoria (État)</li></region><settlement><li>Melbourne</li><li>Sydney</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Lim, Chai K" sort="Lim, Chai K" uniqKey="Lim C" first="Chai K." last="Lim">Chai K. Lim</name></region><name sortKey="Batten, Jane C" sort="Batten, Jane C" uniqKey="Batten J" first="Jane C." last="Batten">Jane C. Batten</name><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><name sortKey="Brew, Bruce J" sort="Brew, Bruce J" uniqKey="Brew B" first="Bruce J." last="Brew">Bruce J. Brew</name><name sortKey="De Rose, Robert" sort="De Rose, Robert" uniqKey="De Rose R" first="Robert" last="De Rose">Robert De Rose</name><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><name sortKey="Guillemin, Gilles J" sort="Guillemin, Gilles J" uniqKey="Guillemin G" first="Gilles J." last="Guillemin">Gilles J. Guillemin</name><name sortKey="Heng, Benjamin" sort="Heng, Benjamin" uniqKey="Heng B" first="Benjamin" last="Heng">Benjamin Heng</name><name sortKey="Kent, Stephen J" sort="Kent, Stephen J" uniqKey="Kent S" first="Stephen J." last="Kent">Stephen J. Kent</name><name sortKey="Lim, Chai K" sort="Lim, Chai K" uniqKey="Lim C" first="Chai K." last="Lim">Chai K. Lim</name><name sortKey="Yap, Margaret M C" sort="Yap, Margaret M C" uniqKey="Yap M" first="Margaret M. C." last="Yap">Margaret M. C. Yap</name></country><country name="France"><noRegion><name sortKey="Gras, Gabriel" sort="Gras, Gabriel" uniqKey="Gras G" first="Gabriel" last="Gras">Gabriel Gras</name></noRegion><name sortKey="Samah, Boubekeur" sort="Samah, Boubekeur" uniqKey="Samah B" first="Boubekeur" last="Samah">Boubekeur Samah</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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